Use of Antistaphylococcal β-Lactams to Increase Daptomycin Activity in Eradicating Persistent Bacteremia Due to Methicillin-Resistant Staphylococcus aureus: Role of Enhanced Daptomycin Binding

We used daptomycin plus antistaphylococcal β-lactams (ASBL) to clear refractory MRSA bacteremia. In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomycin binding, and decrease in positive surface charge induced by ASBLs against daptomycin nonsusceptible MRSA....

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Dades bibliogràfiques
Autors principals: Dhand, Abhay, Bayer, Arnold S., Pogliano, Joseph, Yang, Soo-Jin, Bolaris, Michael, Nizet, Victor, Wang, Guiquing, Sakoulas, George
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697476/
https://ncbi.nlm.nih.gov/pubmed/21690622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/cir340
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