Use of Antistaphylococcal β-Lactams to Increase Daptomycin Activity in Eradicating Persistent Bacteremia Due to Methicillin-Resistant Staphylococcus aureus: Role of Enhanced Daptomycin Binding

We used daptomycin plus antistaphylococcal β-lactams (ASBL) to clear refractory MRSA bacteremia. In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomycin binding, and decrease in positive surface charge induced by ASBLs against daptomycin nonsusceptible MRSA....

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Bibliografiske detaljer
Main Authors: Dhand, Abhay, Bayer, Arnold S., Pogliano, Joseph, Yang, Soo-Jin, Bolaris, Michael, Nizet, Victor, Wang, Guiquing, Sakoulas, George
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697476/
https://ncbi.nlm.nih.gov/pubmed/21690622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/cir340
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