Use of Antistaphylococcal β-Lactams to Increase Daptomycin Activity in Eradicating Persistent Bacteremia Due to Methicillin-Resistant Staphylococcus aureus: Role of Enhanced Daptomycin Binding

We used daptomycin plus antistaphylococcal β-lactams (ASBL) to clear refractory MRSA bacteremia. In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomycin binding, and decrease in positive surface charge induced by ASBLs against daptomycin nonsusceptible MRSA....

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Detalhes bibliográficos
Main Authors: Dhand, Abhay, Bayer, Arnold S., Pogliano, Joseph, Yang, Soo-Jin, Bolaris, Michael, Nizet, Victor, Wang, Guiquing, Sakoulas, George
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697476/
https://ncbi.nlm.nih.gov/pubmed/21690622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/cir340
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