β-Lactam-Induced Cell Envelope Adaptations, Not Solely Enhanced Daptomycin Binding, Underlie Daptomycin-β-Lactam Synergy in Methicillin-Resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious clinical threat due to innate virulence properties, high infection rates, and the ability to develop resistance to multiple antibiotics, including the lipopeptide daptomycin (DAP). The acquisition of DAP resistance (DAP-R) in MRSA has b...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Lew, Cassandra, Mishra, Nagendra N., Bayer, Arnold S., Rose, Warren E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284448/
https://ncbi.nlm.nih.gov/pubmed/34097478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00356-21
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