β-Lactam-Induced Cell Envelope Adaptations, Not Solely Enhanced Daptomycin Binding, Underlie Daptomycin-β-Lactam Synergy in Methicillin-Resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious clinical threat due to innate virulence properties, high infection rates, and the ability to develop resistance to multiple antibiotics, including the lipopeptide daptomycin (DAP). The acquisition of DAP resistance (DAP-R) in MRSA has b...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Lew, Cassandra, Mishra, Nagendra N., Bayer, Arnold S., Rose, Warren E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2021
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284448/
https://ncbi.nlm.nih.gov/pubmed/34097478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00356-21
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