β-Lactam Antibiotics Targeting PBP1 Selectively Enhance Daptomycin Activity against Methicillin-Resistant Staphylococcus aureus

The activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA) is enhanced in the presence of subinhibitory concentrations of antistaphylococcal β-lactam antibiotics by an undefined mechanism. Given the variability in the penicillin-binding protein (PBP)-binding profiles...

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Autores principales: Berti, Andrew D., Sakoulas, George, Nizet, Victor, Tewhey, Ryan, Rose, Warren E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811465/
https://ncbi.nlm.nih.gov/pubmed/23896478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00594-13
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