Toll-Like Receptor 4 Agonistic Antibody Promotes Innate Immunity against Severe Pneumonia Induced by Coinfection with Influenza Virus and Streptococcus pneumoniae

Coinfection with bacteria is a major cause of mortality during influenza epidemics. Recently, Toll-like receptor (TLR) agonists were shown to have immunomodulatory functions. In the present study, we investigated the effectiveness and mechanisms of the new TLR4 agonistic monoclonal antibody UT12 aga...

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Autori principali: Tanaka, Akitaka, Nakamura, Shigeki, Seki, Masafumi, Fukudome, Kenji, Iwanaga, Naoki, Imamura, Yoshifumi, Miyazaki, Taiga, Izumikawa, Koichi, Kakeya, Hiroshi, Yanagihara, Katsunori, Kohno, Shigeru
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Clinical Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697446/
https://ncbi.nlm.nih.gov/pubmed/23637040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00010-13
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