Human Monoclonal Antibodies against Clostridium difficile Toxins A and B Inhibit Inflammatory and Histologic Responses to the Toxins in Human Colon and Peripheral Blood Monocytes

Clostridium difficile infection (CDI) is a common and debilitating nosocomial infection with high morbidity and mortality. C. difficile mediates diarrhea and colitis by releasing two toxins, toxin A and toxin B. Since both toxins stimulate proinflammatory signaling pathways in human colonocytes and...

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Bibliographic Details
Main Authors: Koon, Hon Wai, Shih, David Q., Hing, Tressia C., Yoo, Jun Hwan, Ho, Samantha, Chen, Xinhua, Kelly, Ciarán P., Targan, Stephan R., Pothoulakis, Charalabos
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697353/
https://ncbi.nlm.nih.gov/pubmed/23629713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02633-12
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