Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B-Mediated Inflammatory Responses via Inhibition of NF-κB Activity

Clostridium difficile causes diarrhea and colitis by releasing toxin A and toxin B. In the human colon, both toxins cause intestinal inflammation and stimulate tumor necrosis factor alpha (TNF-α) expression via the activation of NF-κB. It is well established that the macrolide antibiotic fidaxomicin...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Koon, Hon Wai, Wang, Jiani, Mussatto, Caroline C., Ortiz, Christina, Lee, Elaine C., Tran, Diana Hoang-Ngoc, Chen, Xinhua, Kelly, Ciaran P., Pothoulakis, Charalabos
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740352/
https://ncbi.nlm.nih.gov/pubmed/29038278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01513-17
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