Synthesis and evaluation of 7-substituted 4-aminoquinoline analogs for antimalarial activity

We previously reported that substituted 4-aminoquinolines with a phenylether substituent at the 7-position of the quinoline ring and the capability of intramolecular hydrogen bonding between the protonated amine on the side chain and a hydrogen bond acceptor on the amine’s alkyl substituents exhibit...

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Main Authors: Hwang, Jong Yeon, Kawasuji, Takashi, Lowes, David J., Clark, Julie A., Connelly, Michele C., Zhu, Fangyi, Guiguemde, W. Armand, Sigal, Martina S., Wilson, Emily B., DeRisi, Joseph L., Guy, R. Kiplin
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697074/
https://ncbi.nlm.nih.gov/pubmed/21910466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200636z
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