Deregulation of Apoptotic Factors Bcl-xL and Bax Confers Apoptotic Resistance to Myeloid-derived Suppressor Cells and Contributes to Their Persistence in Cancer

Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature myeloid cells that accumulate in response to tumor progression. Compelling data from mouse models and human cancer patients showed that tumor-induced inflammatory mediators induce MDSC differentiation. However, the mechanisms underl...

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Bibliographische Detailangaben
Hauptverfasser: Hu, Xiaolin, Bardhan, Kankana, Paschall, Amy V., Yang, Dafeng, Waller, Jennifer L., Park, Mary Anne, Nayak-Kapoor, Asha, Samuel, Thomas A., Abrams, Scott I., Liu, Kebin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696683/
https://ncbi.nlm.nih.gov/pubmed/23677993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.434530
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