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Hypoxia-inducible Factor-1α (HIF-1α) Promotes Cap-dependent Translation of Selective mRNAs through Up-regulating Initiation Factor eIF4E1 in Breast Cancer Cells under Hypoxia Conditions

Hypoxia promotes tumor evolution and metastasis, and hypoxia-inducible factor-1α (HIF-1α) is a key regulator of hypoxia-related cellular processes in cancer. The eIF4E translation initiation factors, eIF4E1, eIF4E2, and eIF4E3, are essential for translation initiation. However, whether and how HIF-1...

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Detalhes bibliográficos
Main Authors: Yi, Tingfang, Papadopoulos, Evangelos, Hagner, Patrick R., Wagner, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696647/
https://ncbi.nlm.nih.gov/pubmed/23667251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.471466
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