11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

Glucocorticoid (GC) excess adversely affects skin integrity, inducing thinning and impaired wound healing. Aged skin, particularly that which has been photo-exposed, shares a similar phenotype. Previously, we demonstrated age-induced expression of the GC-activating enzyme 11β-hydroxysteroid dehydrog...

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Hauptverfasser: Tiganescu, Ana, Tahrani, Abd A., Morgan, Stuart A., Otranto, Marcela, Desmoulière, Alexis, Abrahams, Lianne, Hassan-Smith, Zaki, Walker, Elizabeth A., Rabbitt, Elizabeth H., Cooper, Mark S., Amrein, Kurt, Lavery, Gareth G., Stewart, Paul M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2013
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696573/
https://ncbi.nlm.nih.gov/pubmed/23722901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64162
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