Melanoma immunotherapy using mature DCs expressing the constitutive proteasome

Background. Many cancers, including melanoma, exclusively express constitutive proteasomes (cPs) and are unable to express immunoproteasomes (iPs). In contrast, mature DCs used for immunotherapy exclusively express iPs. Since proteasomes generate peptides presented by HLA class I molecules, we hypot...

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Bibliografiske detaljer
Main Authors: Dannull, Jens, Haley, N. Rebecca, Archer, Gary, Nair, Smita, Boczkowski, David, Harper, Mark, De Rosa, Nicole, Pickett, Nancy, Mosca, Paul J., Burchette, James, Selim, Maria A., Mitchell, Duane A., Sampson, John, Tyler, Douglas S., Pruitt, Scott K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Clinical Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696565/
https://ncbi.nlm.nih.gov/pubmed/23934126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67544
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