Melanoma immunotherapy using mature DCs expressing the constitutive proteasome

Background. Many cancers, including melanoma, exclusively express constitutive proteasomes (cPs) and are unable to express immunoproteasomes (iPs). In contrast, mature DCs used for immunotherapy exclusively express iPs. Since proteasomes generate peptides presented by HLA class I molecules, we hypot...

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Detalhes bibliográficos
Main Authors: Dannull, Jens, Haley, N. Rebecca, Archer, Gary, Nair, Smita, Boczkowski, David, Harper, Mark, De Rosa, Nicole, Pickett, Nancy, Mosca, Paul J., Burchette, James, Selim, Maria A., Mitchell, Duane A., Sampson, John, Tyler, Douglas S., Pruitt, Scott K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696565/
https://ncbi.nlm.nih.gov/pubmed/23934126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67544
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