Melanoma immunotherapy using mature DCs expressing the constitutive proteasome

Background. Many cancers, including melanoma, exclusively express constitutive proteasomes (cPs) and are unable to express immunoproteasomes (iPs). In contrast, mature DCs used for immunotherapy exclusively express iPs. Since proteasomes generate peptides presented by HLA class I molecules, we hypot...

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Main Authors: Dannull, Jens, Haley, N. Rebecca, Archer, Gary, Nair, Smita, Boczkowski, David, Harper, Mark, De Rosa, Nicole, Pickett, Nancy, Mosca, Paul J., Burchette, James, Selim, Maria A., Mitchell, Duane A., Sampson, John, Tyler, Douglas S., Pruitt, Scott K.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2013
Teme:
Clinical Medicine
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696565/
https://ncbi.nlm.nih.gov/pubmed/23934126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67544
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