Enhancement of Anti-Tumor Immunity Through Local Modulation of CTLA-4 and GITR by Dendritic Cells

Cancer vaccines have now demonstrated clinical efficacy, but immune modulatory mechanisms that prevent autoimmunity limit their effectiveness. Systemic administration of mAbs targeting immune modulatory receptors CTLA-4 and glucocorticoid-induced TNFR-related protein (GITR) on Treg cells and effecto...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Pruitt, Scott K., Boczkowski, David, de Rosa, Nicole, Haley, N. Rebecca, Morse, Michael A., Tyler, Douglas S., Dannull, Jens, Nair, Smita
Formato: Artigo
Idioma:Inglês
Publicado: 2011
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594439/
https://ncbi.nlm.nih.gov/pubmed/22028176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141383
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares