Enhancement of Anti-Tumor Immunity Through Local Modulation of CTLA-4 and GITR by Dendritic Cells

Cancer vaccines have now demonstrated clinical efficacy, but immune modulatory mechanisms that prevent autoimmunity limit their effectiveness. Systemic administration of mAbs targeting immune modulatory receptors CTLA-4 and glucocorticoid-induced TNFR-related protein (GITR) on Treg cells and effecto...

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Hlavní autoři: Pruitt, Scott K., Boczkowski, David, de Rosa, Nicole, Haley, N. Rebecca, Morse, Michael A., Tyler, Douglas S., Dannull, Jens, Nair, Smita
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594439/
https://ncbi.nlm.nih.gov/pubmed/22028176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141383
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