Stabilization of HIF-2alpha through redox regulation of mTORC2 activation and initiation of mRNA translation

HIF-2alpha plays a critical role in renal tumorigenesis. HIF-2alpha is stabilized in Von Hippel-Lindau (VHL)-deficient renal cell carcinoma through mechanisms that require ongoing mRNA translation. Mammalian target of Rapamycin (mTOR) functions in two distinct complexes, Raptor-associated mTORC1 and...

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Detalhes bibliográficos
Main Authors: Nayak, Bijaya K., Feliers, Denis, Sudarshan, Sunil, Friedrichs, William E., Day, Robert T., New, David D., Fitzgerald, John P., Eid, Assaad, DeNapoli, Thomas, Parekh, Dipen J., Gorin, Yves, Block, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696051/
https://ncbi.nlm.nih.gov/pubmed/22869144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.333
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