Androgen Deprivation-Induced Senescence Promotes Outgrowth of Androgen-Refractory Prostate Cancer Cells

Androgen deprivation (AD) is an effective method for initially suppressing prostate cancer (PC) progression. However, androgen-refractory PC cells inevitably emerge from the androgen-responsive tumor, leading to incurable disease. Recent studies have shown AD induces cellular senescence, a phenomeno...

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Autors principals: Burton, Dominick G. A., Giribaldi, Maria G., Munoz, Anisleidys, Halvorsen, Katherine, Patel, Asmita, Jorda, Merce, Perez-Stable, Carlos, Rai, Priyamvada
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695935/
https://ncbi.nlm.nih.gov/pubmed/23840802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068003
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