MTH1 expression is required for effective transformation by oncogenic HRAS

Due to sustaining elevated reactive oxygen species (ROS), oncogenic RAS-transformed cells upregulate redox-protective genes, among them the mammalian 8-oxodGTPase, MutT Homolog 1 (MTH1). We previously showed MTH1 abrogates RAS oncogene-induced senescence (OIS) in normal cells and that its inhibition...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Giribaldi, Maria G., Munoz, Anisleidys, Halvorsen, Katherine, Patel, Asmita, Rai, Priyamvada
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484473/
https://ncbi.nlm.nih.gov/pubmed/25893378
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