MHC Class II–Alpha Chain Knockout Mice Support Increased Viral Replication That Is Independent of Their Lack of MHC Class II Cell Surface Expression and Associated Immune Function Deficiencies

MHCII molecules are heterodimeric cell surface proteins composed of an α and β chain. These molecules are almost exclusively expressed on thymic epithelium and antigen presenting cells (APCs) and play a central role in the development and function of CD4 T cells. Various MHC-II knockout mice have be...

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Bibliographic Details
Main Authors: Alsharifi, Mohammed, Koskinen, Aulikki, Wijesundara, Danushka K., Bettadapura, Jayaram, Müllbacher, Arno
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695910/
https://ncbi.nlm.nih.gov/pubmed/23840854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068458
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