Bidirectional binding of invariant chain peptides to an MHC class II molecule

T-cell recognition of peptides bound to MHC class II (MHCII) molecules is a central event in cell-mediated adaptive immunity. The current paradigm holds that prebound class II-associated invariant chain peptides (CLIP) and all subsequent antigens maintain a canonical orientation in the MHCII binding...

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Main Authors: Günther, Sebastian, Schlundt, Andreas, Sticht, Jana, Roske, Yvette, Heinemann, Udo, Wiesmüller, Karl-Heinz, Jung, Günther, Falk, Kirsten, Rötzschke, Olaf, Freund, Christian
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009805/
https://ncbi.nlm.nih.gov/pubmed/21115828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014708107
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