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The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.

Activators of protein kinase C, such as 12-O-tetradecanoylphorbol 13-acetate (TPA), are known to regulate the expression of many genes, including the tumor necrosis factor alpha (TNF) gene, by affecting the level or activity of upstream transcription factors. To investigate the mechanism whereby TPA...

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Udgivet i:Mol Cell Biol
Principais autores: Leitman, D C, Mackow, E R, Williams, T, Baxter, J D, West, B L
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369568/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1545816/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.3.1352-1356.1992
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