Single-cell paired-end genome sequencing reveals structural variation per cell cycle

The nature and pace of genome mutation is largely unknown. Because standard methods sequence DNA from populations of cells, the genetic composition of individual cells is lost, de novo mutations in cells are concealed within the bulk signal and per cell cycle mutation rates and mechanisms remain elu...

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Hlavní autoři: Voet, Thierry, Kumar, Parveen, Van Loo, Peter, Cooke, Susanna L., Marshall, John, Lin, Meng-Lay, Zamani Esteki, Masoud, Van der Aa, Niels, Mateiu, Ligia, McBride, David J., Bignell, Graham R., McLaren, Stuart, Teague, Jon, Butler, Adam, Raine, Keiran, Stebbings, Lucy A., Quail, Michael A., D’Hooghe, Thomas, Moreau, Yves, Futreal, P. Andrew, Stratton, Michael R., Vermeesch, Joris R., Campbell, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Genomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695511/
https://ncbi.nlm.nih.gov/pubmed/23630320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt345
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