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Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8(+) T cells and dendritic cells
Humans and mice with impaired perforin-dependent cytotoxic function may develop excessive T-cell activation and the fatal disorder hemophagocytic lymphohistiocytosis (HLH) after infection. Though cytotoxic lymphocytes can kill antigen-presenting cells, the physiological mechanism of perforin-mediate...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3695362/ https://ncbi.nlm.nih.gov/pubmed/23660960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-495309 |
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