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Perforin is a critical physiologic regulator of T-cell activation
Individuals with impaired perforin-dependent cytotoxic function (Ctx(−)) develop a fatal inflammatory disorder called hemophagocytic lymphohistiocytosis (HLH). It has been hypothesized that immune hyperactivation during HLH is caused by heightened infection, defective apoptosis/responsiveness of Ctx...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3142903/ https://ncbi.nlm.nih.gov/pubmed/21606480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-324533 |
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