Generation of Recombinant Human Parainfluenza Virus Type 1 Vaccine Candidates by Importation of Temperature-Sensitive and Attenuating Mutations from Heterologous Paramyxoviruses

Human parainfluenza virus type 1 (HPIV1) is a significant cause of respiratory tract disease in infants and young children for which a vaccine is needed. In the present study, we sought to attenuate HPIV1 by the importation of one or more known attenuating point mutations from heterologous paramyxov...

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Publicat a:	J Virol
Autors principals:	Newman, Jason T., Riggs, Jeffrey M., Surman, Sonja R., McAuliffe, Josephine M., Mulaikal, Teresa A., Collins, Peter L., Murphy, Brian R., Skiadopoulos, Mario H.
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2004
Matèries:	Vaccines and Antiviral Agents
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369514/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14747566/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.4.2017-2028.2004
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