Generation of Recombinant Human Parainfluenza Virus Type 1 Vaccine Candidates by Importation of Temperature-Sensitive and Attenuating Mutations from Heterologous Paramyxoviruses

Human parainfluenza virus type 1 (HPIV1) is a significant cause of respiratory tract disease in infants and young children for which a vaccine is needed. In the present study, we sought to attenuate HPIV1 by the importation of one or more known attenuating point mutations from heterologous paramyxov...

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Detalhes bibliográficos
Main Authors: Newman, Jason T., Riggs, Jeffrey M., Surman, Sonja R., McAuliffe, Josephine M., Mulaikal, Teresa A., Collins, Peter L., Murphy, Brian R., Skiadopoulos, Mario H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC369514/
https://ncbi.nlm.nih.gov/pubmed/14747566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.4.2017-2028.2004
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