Generation of Recombinant Human Parainfluenza Virus Type 1 Vaccine Candidates by Importation of Temperature-Sensitive and Attenuating Mutations from Heterologous Paramyxoviruses

Human parainfluenza virus type 1 (HPIV1) is a significant cause of respiratory tract disease in infants and young children for which a vaccine is needed. In the present study, we sought to attenuate HPIV1 by the importation of one or more known attenuating point mutations from heterologous paramyxov...

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Vydáno v:J Virol
Hlavní autoři: Newman, Jason T., Riggs, Jeffrey M., Surman, Sonja R., McAuliffe, Josephine M., Mulaikal, Teresa A., Collins, Peter L., Murphy, Brian R., Skiadopoulos, Mario H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2004
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369514/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14747566/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.4.2017-2028.2004
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