Astrocyte-Specific Overexpression of Insulin-Like Growth Factor-1 Protects Hippocampal Neurons and Reduces Behavioral Deficits following Traumatic Brain Injury in Mice

Traumatic brain injury (TBI) survivors often suffer from long-lasting cognitive impairment that stems from hippocampal injury. Systemic administration of insulin-like growth factor-1 (IGF-1), a polypeptide growth factor known to play vital roles in neuronal survival, has been shown to attenuate post...

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Bibliographic Details
Main Authors: Madathil, Sindhu K., Carlson, Shaun W., Brelsfoard, Jennifer M., Ye, Ping, D’Ercole, A. Joseph, Saatman, Kathryn E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695083/
https://ncbi.nlm.nih.gov/pubmed/23826235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067204
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