Conditional Overexpression of Insulin-Like Growth Factor-1 Enhances Hippocampal Neurogenesis and Restores Immature Neuron Dendritic Processes After Traumatic Brain Injury

Traumatic brain injury (TBI) is associated with neuronal damage or death in the hippocampus, a region critical for cognitive function. Immature neurons within the hippocampal neurogenic niche are particularly susceptible to TBI. Therapeutic strategies that protect immature hippocampal neurons or enh...

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Hauptverfasser: Carlson, Shaun W., Madathil, Sindhu K., Sama, Diana M., Gao, Xiang, Chen, Jinhui, Saatman, Kathryn E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102886/
https://ncbi.nlm.nih.gov/pubmed/25003234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0000000000000092
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