Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells

Spontaneous, submembrane local Ca(2+) releases (LCRs) generated by the sarcoplasmic reticulum in sinoatrial nodal cells, the cells of the primary cardiac pacemaker, activate inward Na(+)/Ca(2+)-exchange current to accelerate the diastolic depolarization rate, and therefore to impact on cycle length....

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Detalhes bibliográficos
Main Authors: Monfredi, Oliver, Maltseva, Larissa A., Spurgeon, Harold A., Boyett, Mark R., Lakatta, Edward G., Maltsev, Victor A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695077/
https://ncbi.nlm.nih.gov/pubmed/23826247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067247
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