DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape

Transposable element (TE) derived sequences comprise half of our genome and DNA methylome, and are presumed densely methylated and inactive. Examination of the genome-wide DNA methylation status within 928 TE subfamilies in human embryonic and adult tissues revealed unexpected tissue-specific and su...

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Autors principals: Xie, Mingchao, Hong, Chibo, Zhang, Bo, Lowdon, Rebecca, Xing, Xiaoyun, Li, Daofeng, Zhou, Xin, Lee, Hyung Joo, Maire, Cecile L., Ligon, Keith L., Gascard, Philippe, Sigaroudinia, Mahvash, Tlsty, Thea D., Kadlecek, Theresa, Weiss, Arthur, O’Geen, Henriette, Farnham, Peggy J., Madden, Pamela A.F., Mungall, Andrew J., Tam, Angela, Kamoh, Baljit, Cho, Stephanie, Moore, Richard, Hirst, Martin, Marra, Marco A., Costello, Joseph F., Wang, Ting
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695047/
https://ncbi.nlm.nih.gov/pubmed/23708189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2649
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