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Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins.

The pancreatic beta-cell-specific expression of the insulin gene is mediated, at least in part, by the interaction of unique trans-acting beta-cell factors with a cis-acting DNA element found within the insulin enhancer (5'-GC CATCTG-3'; referred to as the insulin control element [ICE]) present in t...

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Udgivet i:Mol Cell Biol
Principais autores: Cordle, S R, Henderson, E, Masuoka, H, Weil, P A, Stein, R
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369485/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1996119/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.3.1734-1738.1991
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