TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression

Frequent gene amplification of the receptor-activated calcium-dependent chloride channel TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its involvement in human tumorigenesis has not been previously studied. Here, we show a functional role for TMEM16A in tumor growth. We...

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Main Authors: Duvvuri, Umamaheswar, Shiwarski, Daniel J., Xiao, Dong, Bertrand, Carol, Huang, Xin, Edinger, Robert S., Rock, Jason R., Harfe, Brian D., Henson, Brian J., Kunzelmann, Karl, Schreiber, Rainer, Seethala, Raja S., Egloff, Ann Marie, Chen, Xing, Lui, Vivian W., Grandis, Jennifer R., Gollin, Susanne M.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694774/
https://ncbi.nlm.nih.gov/pubmed/22564524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0475-T
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