TMEM16A/ANO1 inhibits apoptosis via down-regulation of Bim expression

PURPOSE: TMEM16A is a calcium-activated chloride channel that is amplified in a variety of cancers, including 30% of head and neck squamous cell carcinomas (HNSCC), raising the possibility of an anti-apoptotic role in malignant cells. The present study investigated this using a multi-modal, translat...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Godse, Neal R., Khan, Nayel, Yochum, Zachary A., Gomez-Casal, Roberto, Kemp, Carolyn, Shiwarski, Daniel J., Seethala, Raja S., Kulich, Scott, Seshadri, Mukund, Burns, Timothy F., Duvvuri, Umamaheswar
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898434/
https://ncbi.nlm.nih.gov/pubmed/28899969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1561
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