11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo

11β-Hydroxysteroid dehydrogenase 1 (11βHSD1; EC 1.1.1.146) generates active glucocorticoids from inert 11-keto metabolites. However, it can also metabolize alternative substrates, including 7β-hydroxy- and 7-keto-cholesterol (7βOHC, 7KC). This has been demonstrated in vitro but its consequences in v...

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Главные авторы: Mitić, Tijana, Shave, Steven, Semjonous, Nina, McNae, Iain, Cobice, Diego F., Lavery, Gareth G., Webster, Scott P., Hadoke, Patrick W.F., Walker, Brian R., Andrew, Ruth
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier Science 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694296/
https://ncbi.nlm.nih.gov/pubmed/23415904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.02.002
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