The Human Immunodeficiency Virus Type 1 Ribosomal Frameshifting Site Is an Invariant Sequence Determinant and an Important Target for Antiviral Therapy

Human immunodeficiency virus type 1 (HIV-1) utilizes a distinctive form of gene regulation as part of its life cycle, termed programmed −1 ribosomal frameshifting, to produce the required ratio of the Gag and Gag-Pol polyproteins. We carried out a sequence comparison of 1,000 HIV-1 sequences at the...

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Detalhes bibliográficos
Main Authors: Biswas, Preetha, Jiang, Xi, Pacchia, Annmarie L., Dougherty, Joseph P., Peltz, Stuart W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC369415/
https://ncbi.nlm.nih.gov/pubmed/14747573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.4.2082-2087.2004
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