Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD). It is unclear how changes to TDP-43, including nuclear to cytosolic translocation and subs...

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Main Authors: Moujalled, Diane, James, Janine L., Parker, Sarah J., Lidgerwood, Grace E., Duncan, Clare, Meyerowitz, Jodi, Nonaka, Takashi, Hasegawa, Masato, Kanninen, Katja M., Grubman, Alexandra, Liddell, Jeffrey R., Crouch, Peter J., White, Anthony R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694067/
https://ncbi.nlm.nih.gov/pubmed/23840699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067433
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