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Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD). It is unclear how changes to TDP-43, including nuclear to cytosolic translocation and subs...

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書誌詳細
主要な著者: Moujalled, Diane, James, Janine L., Parker, Sarah J., Lidgerwood, Grace E., Duncan, Clare, Meyerowitz, Jodi, Nonaka, Takashi, Hasegawa, Masato, Kanninen, Katja M., Grubman, Alexandra, Liddell, Jeffrey R., Crouch, Peter J., White, Anthony R.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694067/
https://ncbi.nlm.nih.gov/pubmed/23840699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067433
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