Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD). It is unclear how changes to TDP-43, including nuclear to cytosolic translocation and subs...

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Główni autorzy: Moujalled, Diane, James, Janine L., Parker, Sarah J., Lidgerwood, Grace E., Duncan, Clare, Meyerowitz, Jodi, Nonaka, Takashi, Hasegawa, Masato, Kanninen, Katja M., Grubman, Alexandra, Liddell, Jeffrey R., Crouch, Peter J., White, Anthony R.
Format: Artigo
Język:Inglês
Wydane: Public Library of Science 2013
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694067/
https://ncbi.nlm.nih.gov/pubmed/23840699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067433
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