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Conformationally constrained analogs of BAY 59–3074 as novel cannabinoid receptor ligands
To obtain information on the pharmacophoric requirements of the CB1/CB2 partial agonist BAY 59–3074 we have synthesized a series of new conformationally constrained dibenzofuran (4a–d) and dibenzopyran analogs (5). All constrained analogs exhibited reduced binding affinity at both cannabinoid recept...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3693451/ https://ncbi.nlm.nih.gov/pubmed/21880487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.07.017 |
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