A Novel Positron Emission Tomography Imaging Protocol Identifies Seizure-Induced Regional Overactivity of P-Glycoprotein at the Blood–Brain Barrier

Approximately one-third of epilepsy patients are pharmacoresistant. Overexpression of P-glycoprotein and other multidrug transporters at the blood–brain barrier is thought to play an important role in drug-refractory epilepsy. Thus, quantification of regionally different P-glycoprotein activity in t...

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Auteurs principaux: Bankstahl, Jens P., Bankstahl, Marion, Kuntner, Claudia, Stanek, Johann, Wanek, Thomas, Meier, Martin, Ding, Xiao-Qi, Müller, Markus, Langer, Oliver, Löscher, Wolfgang
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2011
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693085/
https://ncbi.nlm.nih.gov/pubmed/21677164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6616-10.2011
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