Alternative Complement Pathway Deficiency Ameliorates Chronic Smoke-Induced Functional and Morphological Ocular Injury

BACKGROUND: Age-related macular degeneration (AMD), a complex disease involving genetic variants and environmental insults, is among the leading causes of blindness in Western populations. Genetic and histologic evidence implicate the complement system in AMD pathogenesis; and smoking is the major e...

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Autori principali: Woodell, Alex, Coughlin, Beth, Kunchithapautham, Kannan, Casey, Sarah, Williamson, Tucker, Ferrell, W. Drew, Atkinson, Carl, Jones, Bryan W., Rohrer, Bärbel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3692454/
https://ncbi.nlm.nih.gov/pubmed/23825688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067894
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