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Smoke Exposure Causes Endoplasmic Reticulum Stress and Lipid Accumulation in Retinal Pigment Epithelium through Oxidative Stress and Complement Activation

Age-related macular degeneration (AMD) is a complex disease caused by genetic and environmental factors, including genetic variants in complement components and smoking. Smoke exposure leads to oxidative stress, complement activation, endoplasmic reticulum (ER) stress, and lipid dysregulation, which...

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Detalhes bibliográficos
Main Authors: Kunchithapautham, Kannan, Atkinson, Carl, Rohrer, Bärbel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031511/
https://ncbi.nlm.nih.gov/pubmed/24711457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.564674
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