Application of Multiplexed Kinase Inhibitor Beads to Study Kinome Adaptations in Drug-Resistant Leukemia

Protein kinases play key roles in oncogenic signaling and are a major focus in the development of targeted cancer therapies. Imatinib, a BCR-Abl tyrosine kinase inhibitor, is a successful front-line treatment for chronic myelogenous leukemia (CML). However, resistance to imatinib may be acquired by...

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Detaylı Bibliyografya
Asıl Yazarlar: Cooper, Matthew J., Cox, Nathan J., Zimmerman, Eric I., Dewar, Brian J., Duncan, James S., Whittle, Martin C., Nguyen, Thien A., Jones, Lauren S., Ghose Roy, Sreerupa, Smalley, David M., Kuan, Pei Fen, Richards, Kristy L., Christopherson, Richard I., Jin, Jian, Frye, Stephen V., Johnson, Gary L., Baldwin, Albert S., Graves, Lee M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691232/
https://ncbi.nlm.nih.gov/pubmed/23826126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066755
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