Application of Multiplexed Kinase Inhibitor Beads to Study Kinome Adaptations in Drug-Resistant Leukemia

Protein kinases play key roles in oncogenic signaling and are a major focus in the development of targeted cancer therapies. Imatinib, a BCR-Abl tyrosine kinase inhibitor, is a successful front-line treatment for chronic myelogenous leukemia (CML). However, resistance to imatinib may be acquired by...

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Detalhes bibliográficos
Main Authors: Cooper, Matthew J., Cox, Nathan J., Zimmerman, Eric I., Dewar, Brian J., Duncan, James S., Whittle, Martin C., Nguyen, Thien A., Jones, Lauren S., Ghose Roy, Sreerupa, Smalley, David M., Kuan, Pei Fen, Richards, Kristy L., Christopherson, Richard I., Jin, Jian, Frye, Stephen V., Johnson, Gary L., Baldwin, Albert S., Graves, Lee M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691232/
https://ncbi.nlm.nih.gov/pubmed/23826126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066755
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