Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 as Candidate Therapeutic Target

Endometrial carcinoma (EC) is the most common gynecologic malignancy in the United States, with limited effective targeted therapies. Endometrial tumors exhibit frequent alterations in protein kinases, yet only a small fraction of the kinome has been therapeutically explored. To identify kinase ther...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Kurimchak, Alison M., Kumar, Vikas, Herrera-Montávez, Carlos, Johnson, Katherine J., Srivastava, Nishi, Davarajan, Karthik, Peri, Suraj, Cai, Kathy Q., Mantia-Smaldone, Gina M., Duncan, James S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710141/
https://ncbi.nlm.nih.gov/pubmed/32994315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.002012
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