Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 as Candidate Therapeutic Target

Endometrial carcinoma (EC) is the most common gynecologic malignancy in the United States, with limited effective targeted therapies. Endometrial tumors exhibit frequent alterations in protein kinases, yet only a small fraction of the kinome has been therapeutically explored. To identify kinase ther...

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Bibliografski detalji
Izdano u:Mol Cell Proteomics
Glavni autori: Kurimchak, Alison M., Kumar, Vikas, Herrera-Montávez, Carlos, Johnson, Katherine J., Srivastava, Nishi, Davarajan, Karthik, Peri, Suraj, Cai, Kathy Q., Mantia-Smaldone, Gina M., Duncan, James S.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2020
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710141/
https://ncbi.nlm.nih.gov/pubmed/32994315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.002012
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