TRAP1 rescues PINK1 loss-of-function phenotypes

PTEN-induced kinase 1 (PINK1) is a serine/threonine kinase that is localized to mitochondria. It protects cells from oxidative stress by suppressing mitochondrial cytochrome c release, thereby preventing cell death. Mutations in Pink1 cause early-onset Parkinson's disease (PD). Consistently, mi...

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Autores principales: Zhang, Li, Karsten, Peter, Hamm, Sabine, Pogson, Joe H., Müller-Rischart, A. Kathrin, Exner, Nicole, Haass, Christian, Whitworth, Alexander J., Winklhofer, Konstanze F., Schulz, Jörg B., Voigt, Aaron
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690968/
https://ncbi.nlm.nih.gov/pubmed/23525905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt132
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