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The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity
Overexpression or mutation of α-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function. We used a whole-genome screen in the fruit fly Drosophila melanogaster to search for novel genetic modifiers of human [...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3271059/ https://ncbi.nlm.nih.gov/pubmed/22319455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002488 |
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