The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity

Overexpression or mutation of α-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function. We used a whole-genome screen in the fruit fly Drosophila melanogaster to search for novel genetic modifiers of human [...

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Autors principals: Butler, Erin K., Voigt, Aaron, Lutz, A. Kathrin, Toegel, Jane P., Gerhardt, Ellen, Karsten, Peter, Falkenburger, Björn, Reinartz, Andrea, Winklhofer, Konstanze F., Schulz, Jörg B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271059/
https://ncbi.nlm.nih.gov/pubmed/22319455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002488
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