α-Synuclein regulation by chaperones in mammalian cells

Neurodegeneration in Parkinson’s disease is correlated with the occurrence of Lewy bodies, intracellular inclusions containing aggregates of the intrinsically disordered protein (IDP) α-Synuclein(1). The aggregation propensity of α-Synuclein in cells is modulated by specific factors including posttr...

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Veröffentlicht in:Nature
Hauptverfasser: Burmann, Björn M., Gerez, Juan A., Matečko-Burmann, Irena, Campioni, Silvia, Kumari, Pratibha, Ghosh, Dhiman, Mazur, Adam, Aspholm, Emelie E., Šulskis, Darius, Wawrzyniuk, Magdalena, Bock, Thomas, Schmidt, Alexander, Rüdiger, Stefan G.D., Riek, Roland, Hiller, Sebastian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930850/
https://ncbi.nlm.nih.gov/pubmed/31802003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1808-9
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