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KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry
Many candidate unnatural DNA base pairs have been developed, but surprisingly, some of the best replicated adopt intercalated structures in free DNA that are difficult to reconcile with known mechanisms of polymerase recognition. Here we present crystal structures of KlenTaq DNA polymerase at differ...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690913/ https://ncbi.nlm.nih.gov/pubmed/22660438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.966 |
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